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Generation of Mkk4 ACKO mice . Mkk4 was specifically deleted from the atria of the heart using the Cre‐LoxP system.Mkk4 flox/flox (Mkk4 F/F) mice 14 were crossed with Nppa‐Cre4 mice, which express CRE only in atrial cardiomyocytes, 16 to generate atrial‐specific Mkk4 knockout mice (Mkk4 ACKO).The Nppa‐Cre4 line (kindly provided by Dr. V.M. Christoffels) is a. 1 - 20 of 4,967 for L. J. Shen. Books close Remove Books. Available In Stores. Filters. keyboard_arrow_down. Books close Remove Books. Subject. keyboard_arrow_left. History (1,315) Fiction ... Age Range. keyboard_arrow_left. 3-5 Years (6) 6-8 Years (15) 9-12 Years (9) Teens (10) Language. keyboard_arrow_left. English (4,591) German (154.

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